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YARA İZİ GİDERME VE DOKU REJENERASYONU İÇİN ELEKTROSPUN NANOFİBERLERDEKİ GELİŞMELER

Yıl 2025, Cilt: 32 Sayı: 138, 192 - 209, 30.06.2025

Elçin Tören

Öz

Nanoteknoloji, doku rejenerasyonunu teşvik etmek ve yara izlerini azaltmak için benzersiz çözümler sunarak yara iyileşmesi ve yara izlerinin giderilmesi için umut verici bir yaklaşım olarak ortaya çıkmıştır. Elektrospunnanofiberler, hücre dışı matrisi taklit etme ve hücre yapışması, çoğalması ve farklılaşması için ideal bir ortam sağlama yetenekleri nedeniyle büyük ilgi görmüştür. Bu kapsamlı inceleme, yara izi yönetimi için elektroeğirme ile ilgili nanoteknolojideki son gelişmeleri araştırmakta, üretim tekniklerine, terapötik uygulamalara ve güvenlik hususlarına odaklanmaktadır. İğne tabanlı, iğnesiz, eriyik, emülsiyon ve çözelti elektrospinningdahil olmak üzere çeşitli elektrospinning yöntemleri, avantajları ve sınırlamaları vurgulanarak tartışılmıştır. İlaçlar, büyüme faktörleri ve kök hücreler gibi terapötik ajanların elektroeğirilmişnanolifleredahil edilmesinin yara iyileşmesini desteklediği ve yara izi oluşumunu azalttığı gösterilmiştir. Bununla birlikte, bu nanomalzemelerinbiyouyumluluğu ve güvenliği, uzun vadeli güvenlik ve etkinliklerini sağlamak için titiz araştırmalar gerektiren endişeler olmaya devam etmektedir. Nanoteknoloji temelli yara izi tedavisinin potansiyel toksisitesi, biyo-dağılımı, bağışıklık tepkisi ve düzenleyici yönleri eleştirel bir şekilde incelenmiştir. Bu zorluklara rağmen, yara yönetiminde elektrospunnanoteknolojinin gelecekteki beklentileri, yara bakımında devrim yaratma ve hasta sonuçlarını iyileştirme potansiyeli ile umut vericidir. Bu alanda daha fazla araştırma ve geliştirme yapılması, yara izi tedavisi için elzemdir.

Anahtar Kelimeler

Elektrospun nanofiberler Yara iyileşmesi Yara izi yönetimi Nanoteknoloji Doku rejenerasyonu

Kaynakça

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ADVANCES IN ELECTROSPUN NANOFIBERS FOR SCAR REMOVAL AND TISSUE REGENERATION

Yıl 2025, Cilt: 32 Sayı: 138, 192 - 209, 30.06.2025

Elçin Tören

Öz

Nanotechnology has emerged as a promising approach for wound healing and scar removal, offering unique solutions to promote tissue regeneration and reduce scarring. Electrospun nanofibers have gained significant attention owing to their ability to mimic the extracellular matrix and provide an ideal environment for cell adhesion, proliferation, and differentiation. This comprehensive review explores recent advances in electrospinning-related nanotechnology for scar management, focusing on fabrication techniques, therapeutic applications, and safety considerations. Various electrospinning methods, including needle-based, needleless, melt, emulsion, and solution electrospinning, have been discussed, highlighting their advantages and limitations. The incorporation of therapeutic agents such as drugs, growth factors, and stem cells into electrospun nanofibers has been shown to promote wound healing and reduce scar formation. However, the biocompatibility and safety of these nanomaterials remain concerns, necessitating rigorous research to ensure their long-term safety and efficacy. The potential toxicity, biodistribution, immune response, and regulatory aspects of nanotechnology-based scar treatment have been critically examined. Despite these challenges, the future prospects of electrospun nanotechnology in scar management are promising, with the potential to revolutionize wound care and improve patient outcomes. Further research and development in this field are essential for transforming these innovative approaches into clinical practice.

Anahtar Kelimeler

Electrospun nanofibers Wound healing Scar management Nanotechnology Tissue regeneration

Kaynakça

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  • Yu H, Chen X, Cai J, Ye D, Wu Y, Fan L, et al. Novel porous three-dimensional nanofibrous scaffolds for accelerating wound healing. Chemical Engineering Journal 2019;369:253–62. https://doi. org/10. 1016/j. cej. 2019. 03. 091.
  • Kim HN, Hong Y, Kim MS, Kim SM, Suh K-Y. Effect of orientation and density of nanotopography in dermal wound healing. Biomaterials 2012;33:8782–92. https://doi. org/10. 1016/j. biomaterials. 2012. 08. 038.
  • Sun L, Gao W, Fu X, Shi M, Xie W, Zhang W, et al. Enhanced wound healing in diabetic rats by nanofibrous scaffolds mimicking the basketweave pattern of collagen fibrils in native skin. Biomater Sci 2018;6:340–9. https://doi. org/10. 1039/C7BM00545H.
  • Dubský M, Kubinová Š, Širc J, Voska L, Zajíček R, Zajícová A, et al. Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing. J Mater Sci: Mater Med 2012;23:931–41. https://doi. org/10. 1007/s10856-012-4577-7.
  • Chantre CO, Campbell PH, Golecki HM, Buganza AT, Capulli AK, Deravi LF, et al. Production-scale fibronectin nanofibers promote wound closure and tissue repair in a dermal mouse model. Biomaterials 2018;166:96–108. https://doi. org/10. 1016/j. biomaterials. 2018. 03. 006.
  • Hsu F-Y, Hung Y-S, Liou H-M, Shen C-H. Electrospun hyaluronate–collagen nanofibrous matrix and the effects of varying the concentration of hyaluronate on the characteristics of foreskin fibroblast cells. Acta Biomaterialia 2010;6:2140–7. https://doi. org/10. 1016/j. actbio. 2009. 12. 023.
  • Chen J-P, Chang G-Y, Chen J-K. Electrospun collagen/chitosan nanofibrous membrane as wound dressing. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2008;313–314:183–8. https://doi. org/10. 1016/j. colsurfa. 2007. 04. 129.
  • Choi JS, Leong KW, Yoo HS. In vivo wound healing of diabetic ulcers using electrospun nanofibers immobilized with human epidermal growth factor (EGF). Biomaterials 2008;29:587–96. https://doi. org/10. 1016/j. biomaterials. 2007. 10. 012.
  • Choi JS, Choi SH, Yoo HS. Coaxial electrospun nanofibers for treatment of diabetic ulcers with binary release of multiple growth factors. J Mater Chem 2011;21:5258–67. https://doi. org/10. 1039/C0JM03706K.
  • Garcia-Orue I, Gainza G, Gutierrez FB, Aguirre JJ, Evora C, Pedraz JL, et al. Novel nanofibrous dressings containing rhEGF and Aloe vera for wound healing applications. International Journal of Pharmaceutics 2017;523:556–66. https://doi. org/10. 1016/j. ijpharm. 2016. 11. 006.
  • Lai H-J, Kuan C-H, Wu H-C, Tsai J-C, Chen T-M, Hsieh D-J, et al. Tailored design of electrospun composite nanofibers with staged release of multiple angiogenic growth factors for chronic wound healing. Acta Biomaterialia 2014;10:4156–66. https://doi. org/10. 1016/j. actbio. 2014. 05. 001.
  • Xie Z, Paras CB, Weng H, Punnakitikashem P, Su L-C, Vu K, et al. Dual growth factor releasing multi-functional nanofibers for wound healing. Acta Biomaterialia 2013;9:9351–9. https://doi. org/10. 1016/j. actbio. 2013. 07. 030.
  • Yuan Z, Zhao J, Chen Y, Yang Z, Cui W, Zheng Q. Regulating Inflammation Using Acid-Responsive Electrospun Fibrous Scaffolds for Skin Scarless Healing. Mediators of Inflammation 2014;2014:858045. https://doi. org/10. 1155/2014/858045.
  • Mohiti-Asli M, Saha S, Murphy S v. , Gracz H, Pourdeyhimi B, Atala A, et al. Ibuprofen loaded PLA nanofibrous scaffolds increase proliferation of human skin cells in vitro and promote healing of full thickness incision wounds in vivo. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2017;105:327–39. https://doi. org/10. 1002/jbm. b. 33520.
  • Ren X, Han Y, Wang J, Jiang Y, Yi Z, Xu H, et al. An aligned porous electrospun fibrous membrane with controlled drug delivery – An efficient strategy to accelerate diabetic wound healing with improved angiogenesis. Acta Biomaterialia 2018;70:140–53. https://doi. org/10. 1016/j. actbio. 2018. 02. 010.
  • Liu X, Lin T, Gao Y, Xu Z, Huang C, Yao G, et al. Antimicrobial electrospun nanofibers of cellulose acetate and polyester urethane composite for wound dressing. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2012;100B:1556–65. https://doi. org/10. 1002/jbm. b. 32724.
  • Poormasjedi-Meibod M-S, Salimi Elizei S, Leung V, Baradar Jalili R, Ko F, Ghahary A. Kynurenine Modulates MMP-1 and Type-I Collagen Expression Via Aryl Hydrocarbon Receptor Activation in Dermal Fibroblasts. Journal of Cellular Physiology 2016;231:2749–60. https://doi. org/10. 1002/jcp. 25383.
  • Vargas EAT, do Vale Baracho NC, de Brito J, de Queiroz AAA. Hyperbranched polyglycerol electrospun nanofibers for wound dressing applications. Acta Biomaterialia 2010;6:1069–78. https://doi. org/10. 1016/j. actbio. 2009. 09. 018.
  • Jung S-M, Min SK, Lee HC, Kwon YS, Jung MH, Shin HS. Spirulina-PCL Nanofiber Wound Dressing to Improve Cutaneous Wound Healing by Enhancing Antioxidative Mechanism. Journal of Nanomaterials 2016;2016:6135727. https://doi. org/10. 1155/2016/6135727.
  • Tören E, Mazari A, Buzgo M. Exploring the efficacy of AHA–BHA infused nanofiber skin masks as a topical treatment for acne vulgaris. Journal of Applied Polymer Science 2024;141. https://doi. org/10. 1002/app. 55203.
  • Paiva-Santos AC, Mascarenhas-Melo F, Coimbra SC, Pawar KD, Peixoto D, Chá-Chá R, et al. Nanotechnology-based formulations toward the improved topical delivery of anti-acne active ingredients. Expert Opinion on Drug Delivery 2021;18:1435–54. https://doi. org/10. 1080/17425247. 2021. 1951218.
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  • Suamte L, Babu PJ. Electrospun based functional scaffolds for biomedical engineering: A review. Nano TransMed 2024:100055. https://doi. org/10. 1016/j. ntm. 2024. 100055.
  • Tören E, Mazari A. Pullulan/Collagen Scaffolds Promote Chronic Wound Healing via Mesenchymal Stem Cells. Micro 2024;4. https://doi. org/10. 3390/micro4040037.
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  • Hornos Carneiro MF, Barbosa F. Gold nanoparticles: A critical review of therapeutic applications and toxicological aspects. J Toxicol Environ Health B Crit Rev 2016;19:129–48. https://doi. org/10. 1080/10937404. 2016. 1168762.
  • Kumar M, Kulkarni P, Liu S, Chemuturi N, Shah DK. Nanoparticle biodistribution coefficients: A quantitative approach for understanding the tissue distribution of nanoparticles. Adv Drug Deliv Rev 2023;194:114708. https://doi. org/10. 1016/j. addr. 2023. 114708.
  • Mohammapdour R, Ghandehari H. Mechanisms of immune response to inorganic nanoparticles and their degradation products. Adv Drug Deliv Rev 2022;180:114022. https://doi. org/10. 1016/j. addr. 2021. 114022.
  • Lewinski N, Colvin V, Drezek R. Cytotoxicity of nanoparticles. Small 2008;4:26–49. https://doi. org/10. 1002/smll. 200700595.
  • Balfourier A, Luciani N, Wang G, Lelong G, Ersen O, Khelfa A, et al. Unexpected intracellular biodegradation and recrystallization of gold nanoparticles. Proc Natl Acad Sci U S A 2020;117:103–13. https://doi. org/10. 1073/pnas. 1911734116.
  • Hasan A, Morshed M, Memic A, Hassan S, Webster TJ, Marei HE-S. Nanoparticles in tissue engineering: applications, challenges and prospects. Int J Nanomedicine 2018;13:5637–55. https://doi. org/10. 2147/IJN. S153758.
  • Maurer-Jones MA, Bantz KC, Love SA, Marquis BJ, Haynes CL. Toxicity of therapeutic nanoparticles. Nanomedicine (Lond) 2009;4:219–41. https://doi. org/10. 2217/17435889. 4. 2. 219.
Toplam 139 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Tekstil Bilimleri ve Mühendisliği (Diğer)
Bölüm Makaleler
Yazarlar

Elçin Tören

Yayımlanma Tarihi 30 Haziran 2025
Gönderilme Tarihi 4 Mart 2025
Kabul Tarihi 24 Nisan 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 32 Sayı: 138

Kaynak Göster

APA Tören, E. (2025). YARA İZİ GİDERME VE DOKU REJENERASYONU İÇİN ELEKTROSPUN NANOFİBERLERDEKİ GELİŞMELER. Tekstil Ve Mühendis, 32(138), 192-209.
AMA Tören E. YARA İZİ GİDERME VE DOKU REJENERASYONU İÇİN ELEKTROSPUN NANOFİBERLERDEKİ GELİŞMELER. Tekstil ve Mühendis. Haziran 2025;32(138):192-209.
Chicago Tören, Elçin. “YARA İZİ GİDERME VE DOKU REJENERASYONU İÇİN ELEKTROSPUN NANOFİBERLERDEKİ GELİŞMELER”. Tekstil Ve Mühendis 32, sy. 138 (Haziran 2025): 192-209.
EndNote Tören E (01 Haziran 2025) YARA İZİ GİDERME VE DOKU REJENERASYONU İÇİN ELEKTROSPUN NANOFİBERLERDEKİ GELİŞMELER. Tekstil ve Mühendis 32 138 192–209.
IEEE E. Tören, “YARA İZİ GİDERME VE DOKU REJENERASYONU İÇİN ELEKTROSPUN NANOFİBERLERDEKİ GELİŞMELER”, Tekstil ve Mühendis, c. 32, sy. 138, ss. 192–209, 2025.
ISNAD Tören, Elçin. “YARA İZİ GİDERME VE DOKU REJENERASYONU İÇİN ELEKTROSPUN NANOFİBERLERDEKİ GELİŞMELER”. Tekstil ve Mühendis 32/138 (Haziran 2025), 192-209.
JAMA Tören E. YARA İZİ GİDERME VE DOKU REJENERASYONU İÇİN ELEKTROSPUN NANOFİBERLERDEKİ GELİŞMELER. Tekstil ve Mühendis. 2025;32:192–209.
MLA Tören, Elçin. “YARA İZİ GİDERME VE DOKU REJENERASYONU İÇİN ELEKTROSPUN NANOFİBERLERDEKİ GELİŞMELER”. Tekstil Ve Mühendis, c. 32, sy. 138, 2025, ss. 192-09.
Vancouver Tören E. YARA İZİ GİDERME VE DOKU REJENERASYONU İÇİN ELEKTROSPUN NANOFİBERLERDEKİ GELİŞMELER. Tekstil ve Mühendis. 2025;32(138):192-209.