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Pediatrik Ailesel Akdeniz Ateşinde Antioksidan İçerikleri ve Oksidatif Stres Belirteci

Yıl 2025, Cilt: 18 Sayı: 1, 17 - 39, 30.04.2025

Amani Yasin , Halit Demir , Lokman Üstyol , Şükran Akgeyik , Rabia Akgeyik , Canan Demir

https://doi.org/10.52976/vansaglik.1535898

Öz

Özet:
Amaç: "Ailesel Akdeniz Ateşi (FMF), tekrarlayan ateş atakları ve serozit ile tanımlanan genetik olmayan bir patolojidir. FMF geninin (MEFV) varyantları ağırlıklı olarak Akdeniz bölgesinde yaşayan hastalarda tespit edilmiştir. Bu çalışma, FMF tanısı konan çocuklarda antioksidanların ve oksidatif stresin aktivitesini göstermeyi amaçlamaktadır.
Gereç ve Yöntem: Çalışma materyali, Ailesel Akdeniz Ateşi tanısı konan 0-18 yaş aralığındaki 35 hasta ve 35 sağlıklı katılımcıdan oluşuyordu. Çalışma 2016-2017 yılları arasında gerçekleştirilmiştir. Örnekler, Yüzüncü Yıl Üniversitesi Tıp Fakültesi Eğitim ve Araştırma Hastanesi Çocuk Sağlığı ve Hastalıkları Kliniği ve Araştırma Laboratuvarı Merkezi'nin onayından sonra alınmıştır. FMF tanısı konan hastalardan alınan serum örneklerinde enzimatik antioksidan aktiviteler (GSH, GPx ve SOD) ve lipid peroksidasyonunun son ürününü temsil eden malondialdehit (MDA) seviyesi ortaya konmuştur. Analizlerin tamamı SPSS istatistik yazılım paketi kullanılarak yapılmıştır
Bulgular: Hastaların serumlarındaki tahmini GSH aktivitesinde, karşılaştırma gruplarıyla karşılaştırıldığında önemsiz bir sapma fark edildi. Hasta grupları, sağlıklı kontrol grubuna göre belirgin şekilde daha düşük ve istatistiksel anlamlılık gösteren SOD aktivitesi sergiledi (p<0.001). Ayrıca, serum GPx aktivitesinde kontrol grubuna göre anlamlı bir fark saptanmadı. Serum malondialdehit (MDA) konsantrasyonu kontrol gruplarına göre anlamlı olarak yükseldi. GSH ve GPx ortalamalarındaki farkın istatistiksel olarak önemsiz olduğu, ancak MDA ve SOD ortalamalarının hasta ve kontrol grupları arasındaki varyansının istatistiksel olarak anlamlı olduğu bulundu (p<0.05). Bu nedenle, Ailesel Akdeniz Ateşi bozukluğuna maruz kalan hastalarda MDA seviyeleri yükselmiştir. Başlangıçta, SOD ve GSH gibi antioksidan enzimlerin aktivitesi azalmıştır.
Sonuç: Bu gerekçelerin bir sonucu olarak, FMF hastaları için klinik uygulamalarda alternatif yöntemler gösterilmelidir. Antioksidan enzimler, hastalığın altında yatan nedenleri ve etiyopatogenezini değiştirebilir. Sonuç olarak, bulgularımızdan, Ailesel Akdeniz Ateşi (FMF) ilerlemesinin nedeninin, antioksidanlar ve oksidatif stres (OS) seviyeleri arasındaki bozulma ve dengesizliğin sonucu olabileceği sonucuna vardık.

Anahtar Kelimeler

FMF GSH GPx SOD and MDA.

Etik Beyan

The study was approved by the Yüzüncü Yıl University Faculty of Medicine Clinical Research Ethics Committee. The present study strictly followed the principles outlined in the Declaration of Helsinki. Informed consent was obtained from the participants of this study.

Kaynakça

  • Akalin N, Bes C, Harmankaya O, Ertürk K, Okuturlar Y, Kumbasar B. (2015). Comparison of inflammation effects in the patients with familial mediterranean fever and dialysis patients. International Journal of Urology and Nephrology, 3(3), 82-89.
  • Alesh MB, Keti DB, Kisaarslan AP, Muhtaroğlu S, Taşkin, S. N. (2022). Hidden threat in familial Mediterranean fever: subclinical inflammation, oxidative stress and their relationship with vitamin D status. Turkish Journal of Medical Sciences, 52(1), 67-75.
  • Ansari MA, Scheff SW. (2010). Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex. Journal of Neuropathology & Experimental Neurology, 69(2), 155-167.
  • Arıtürk ÖK, Üreten K, Sarı M, Yazıhan N, Ermiş E, Ergüder İ. (2013). Relationship of paraoxonase-1, malondialdehyde and mean platelet volume with markers of atherosclerosis in familial Mediterranean fever: an observational study. Anadolu Kardiyol Derg, 13(4), 357-362.
  • Bedard K, Krause KH. (2007). The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiological reviews, 87(1), 245-313.
  • Beutler E, Duron O, Kelly B. (1963). Improved methods for determination of blood gluthatione. J Lab Clin Med, 61, 882-888.
  • Böhm EW, Buonfiglio F, Voigt A M, Bachmann P, Safi T, Pfeiffer N, Gericke A. (2023). Oxidative stress in the eye and its role in the pathophysiology of ocular diseases. Redox Biology, 102967.
  • Brik R, Shinawi M, Kepten I, Berant M, Gershoni-Baruch R. (1999). Familial Mediterranean fever: clinical and genetic characterization in a mixed pediatric population of Jewish and Arab patients. Pediatrics, 103(5), e70-e70.
  • Çekiç SD, Çetinkaya A, Avan AN, Apak R. (2013). Correlation of Total Antioxidant Capacity with Reactive Oxygen Species (ROS) Consumption Measured by Oxidative Conversion. J. Agric. Food Chem., 61(22), 5260-5270.
  • Demirkaya E, Ozen S, Saglam C, Turker T, Duzova A, Woo P, Konè-Paut I, Doglio M, Amarian G, Frenkel J. (2013). PReS-FINAL-2207: Results from a multicenter international registry of Familial Mediterranean Fever: validation of the new set of pediatric diagnostic criteria. Pediatric Rheumatology, 11(2), 1-2.
  • Didžiapetrienė J, Bublevič J, Smailytė G, Kazbarienė B, Stukas R. (2014). Significance of blood serum catalase activity and malondialdehyde level for survival prognosis of ovarian cancer patients. Medicina, 50(4), 204-208.
  • Dinç G, Fentoğlu Ö, Doğru A, İlhan İ, Kırzıoğlu FY, Orhan H. (2018). The evaluation of salivary oxidative stress in patients with familial Mediterranean fever and chronic periodontitis. Journal of periodontology, 89(9), 1112-1120.
  • Ediz L, Ozkol H, Tekeoglu I, Tuluce Y, Gulcu E, Koyuncu I. (2011). Increased oxidative stress in patients with familial Mediterranean fever during attack period. African health sciences, 11, 6-13.
  • Erden M, Ediz L, Hız Ö, Tuluce Y, Ozkol H, Toprak M, Demirdag F. (2012). Effect of colchicine on total antioxidant capacity, antioxidant enzymes and oxidative stress markers in patients with knee osteoarthritis. International Journal of Clinical Medicine, 3(05), 377-382.
  • Espinoza SE, Guo H, Fedarko N, DeZern A, Fried LP, Xue QL, Leng S, Beamer B, Walston JD. (2008). Glutathione peroxidase enzyme activity in aging. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 63(5), 505-509.
  • Forman HJ, Zhang H. (2021). Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nature Reviews Drug Discovery, 20(9), 689-709.
  • Gül A, Ozdogan H, Erer B, Ugurlu S, Kasapcopur O, Davis N, Sevgi S. (2015). Efficacy and safety of canakinumab inadolescents and adults with colchicine-resistant familial Mediterranean fever. Arthritis Research & Therapy, 17(243).
  • Gulcin İ. (2020). Antioxidants and antioxidant methods: An updated overview. Archives of toxicology, 94(3), 651-715
  • Gürbüz Ö, Bağci B, Hüzmeli C, Bağci G, Candan F. (2016). Glutathione-S-transferase variants are not associated with increased carotid intima-media thickness in turkish familial mediterranean fever patients. Archives of Rheumatology, 31(2), 112.
  • Gutteridge JM. (1995). Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clinical Chemistry, 41(12), 1819-1828.
  • Guzel S, Andican G, Seven A, Aslan M, Bolayirli M, Guzel EC, Hamuryudan V. (2012). Acute phase response and oxidative stress status in familial Mediterranean fever (FMF). Modern rheumatology, 22(3), 431-437.
  • Hybertson, B. M., Gao, B., Bose, S. K., & McCord, J. M. (2011). Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Molecular aspects of medicine, 32(4-6), 234-246.
  • Jin, S., & Kang, P. M. (2024). A systematic review on advances in management of oxidative stress-associated cardiovascular diseases. Antioxidants, 13(8), 923.
  • Karaguezyan K, Haroutjunian V, Mamiconyan R, Hakobian G, Nazaretian E, Hovsepyan L, Hoveyan G, Gevorkian E, Hovakimyan S, Zakarian A. (1996). Evidence of oxidative stress in erythrocyte phospholipid composition in the pathogenesis of familial Mediterranean fever (periodical disease). Journal of clinical pathology, 49(6), 453-455.
  • Kilic A, Varkal MA, Durmus MS, Yildiz I, Yıldırım ZNY, Turunc G, Oguz F, Sidal M, Omeroglu RE, Emre S. (2015). Relationship between clinical findings and genetic mutations in patients with familial Mediterranean fever. Pediatric Rheumatology, 13(1), 1-9.
  • Ktsoyan ZA, Beloborodova NV, Sedrakyan AM, Osipov GA, Khachatryan ZA, Manukyan GP, Arakelova KA, Hovhannisyan AI, Arakelyan AA, Ghazaryan KA. (2013). Management of familial Mediterranean fever by colchicine does not normalize the altered profile of microbial long chain fatty acids in the human metabolome. Frontiers in cellular and infection microbiology, 3, 2.
  • Kucuk A, Uslu AU, Arslan S, Balta S, Ozturk C, Uysal S, Kayrak M. (2016). Ischemia-modified albumin and atherosclerosis in patients with familial Mediterranean fever. Angiology, 67(5), 456-460.
  • Lancieri M, Bustaffa M, Palmeri S, Prigione I, Penco F, Papa R, Gattorno M. (2023). An update on familial Mediterranean fever. International Journal of Molecular Sciences, 24(11), 9584.
  • Lü JM, Lin PH, Yao Q, Chen C. (2010). Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. Journal of Cellular and Molecular Medicine, 14(4), 840-860.
  • Mattit H, Joma M, Al-Cheikh S, El-Khateeb M, Medlej-Hashim M, Salem N, Mégarbané A. (2006). Familial Mediterranean fever in the Syrian population: gene mutation frequencies, carrier rates and phenotype–genotype correlation. European journal of medical genetics, 49(6), 481-486.
  • Michiels C, Raes M, Toussaint O, Remacle J. (1994). Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-SOD for cell survival against oxidative stress. Free radical Biology and medicine, 17(3), 235-248.
  • Milenković J, Vojinović J, Debeljak M, Toplak N, Lazarević D, Avčin T, Jevtović-Stoimenov T, Pavlović D, Bojanić V, Milojković M. (2016). Distribution of MEFV gene mutations and R202Q polymorphism in the Serbian population and their influence on oxidative stress and clinical manifestations of inflammation. Pediatric Rheumatology, 14(1), 1-9.
  • Morano KA, Grant CM, Moye-Rowley WS. (2012). The response to heat shock and oxidative stress in Saccharomyces cerevisiae. Genetics, 190(4), 1157-1195.
  • Onur H, Aral H, Arica V, Bercem GA, Kasapcopur O. (2016). Vitamin D levels in children with familial Mediterranean fever. Pediatric Rheumatology, 14, 1-5.
  • Özer S, Yılmaz R, Sönmezgöz E, Karaaslan E, Taşkın S, Bütün İ, Demir O. (2015). Simple markers for subclinical inflammation in patients with Familial Mediterranean Fever. Medical Science Monitor: İnternational medical journal of experimental and clinical research, 21, 298.
  • Peters RS, Lehman TJ, Schwabe AD. (1983). Colchicine use for familial Mediterranean fever—observations associated with long-term treatment. Western Journal of Medicine, 138(1), 43.
  • Poljsak B, Šuput D, Milisav I. (2013). Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants. Oxidative Medicine and Cellular Longevity, 2013, 1-11.
  • Popov B, Gadjeva V, Valkanov P, Popova S, Tolekova A. (2003). Lipid peroxidation, superoxide dismutase and catalase activities in brain tumor tissues. Archives of physiology and biochemistry, 111(5), 455-459.
  • Rabinovich E. (2005). Severe disease in patients with rheumatoid arthritis carrying a mutation in the Mediterranean fever gene. Annals of the Rheumatic Diseases, 64(7), 1009-1014.
  • Rabinovich E, Livneh A, Langevitz P, Brezniak N, Shinar E, Pras M, Shinar Y. (2005). Severe disease in patients with rheumatoid arthritis carrying a mutation in the Mediterranean fever gene. Annals of the Rheumatic Diseases, 64(7), 1009-1014.
  • Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, Dhama K. (2014). Oxidative stress, prooxidants, and antioxidants: the interplay. BioMed research international, 2014.
  • Romano M, Garcia-Bournissen F, Piskin D, Rodoplu U, Piskin L, Elzagallaai AA, Honca T. (2022). Anti-inflammatory, antioxidant, and anti-atherosclerotic effects of natural supplements on patients with FMF-related AA amyloidosis: a non-randomized 24-week open-label interventional study. Life, 12(6), 896.
  • Salehzadeh F. (2015). Familial Mediterranean fever in Iran: a report from FMF registration center. International journal of rheumatology, 2015.
  • Santos DF, Simão S, Nóbrega C, Bragança J, Castelo‐Branco P, Araújo IM, Consortium AS. (2024). Oxidative stress and aging: synergies for age related diseases. FEBS letters, 598(17), 2074-2091.
  • Schwabe AD, Terasaki PI, Barnett EV, Territo MC, Klinenberg JR, Peters RS. (1977). Familial Mediterranean fever: recent advances in pathogenesis and management. Western Journal of Medicine, 127(1), 15.
  • Sharma SL, Chokshi SA, Chakraborti C. (2014). Enzymatic Antioxidants, Malondialdehyde, and Total Antioxidant Activity as Markers of Oxidative-Stress in Arthritis and Rheumatoid Arthritis. NHL Journal of Medical Sciences, 3(2).
  • Tufan A, LACHMANN H. (2020). Familial Mediterranean fever, from pathogenesis to treatment: a contemporary review. Turkish Journal of Medical Sciences, 50(10), 1591-1610.
  • Valko M, Morris H, Cronin M. (2005). Metals, toxicity and oxidative stress. Current medicinal chemistry, 12(10), 1161-1208.
  • Yilmaz R, Ozer S. (2010). A rare presentation of familial Mediterranean fever; acute scrotum and hydrocele amyloidosis. Iranian Journal of Pediatrics, 20(3), 367.
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Antioxidant Contents and Oxidative Stress Markers in Pediatric Familial Mediterranean Fever

Yıl 2025, Cilt: 18 Sayı: 1, 17 - 39, 30.04.2025

Amani Yasin , Halit Demir , Lokman Üstyol , Şükran Akgeyik , Rabia Akgeyik , Canan Demir

https://doi.org/10.52976/vansaglik.1535898

Öz

ABSTRACT:
Objective: Familial Mediterranean fever (FMF) is a non-genomic latent pathosis delineated by iterative attacks of fever with serositis. Variants of the FMF gene (MEFV) have been detected predominantly in patients from Mediterranean inhabitants. This study contemplates demonstrating the activity of antioxidants and oxidative stress in children diagnosed with FMF.
Material and Method: The study material comprised a range of 0-18 years of age of 35 individuals diagnosed with Familial Mediterranean Fever compared to 35 healthy participants. The study was conducted between 2016-2017. The samples were taken after the approval of Yüzüncü Yıl University, Medical Faculty of Research, education and Training Hospital, Department of Pediatric Health and Diseases Clinic and Research Laboratory Center. The studied enzymatic antioxidant activities as in (GSH, GPx, and SOD) and the malondialdehyde (MDA) level, which represents the end product of the lipid peroxidation process, the differences were revealed in the serum samples collected in distinction to patients diagnosed with FMF. The entirety of the analyses was conducted utilizing the SPSS statistics software package.
Results: In the estimation activity of GSH for the sera of patients, insignificant divergence was noticed at the time contrasted with comparator groups. The patient groups exhibited SOD activity that was revealed to be notably lower versus the healthy control group, showing statistical significance (p<0.001). Besides, no significant difference in serum GPx activity was discerned relative to the control group. The serum malondialdehyde (MDA) concentration was significantly elevated compared to the control groups. The distinction in the averages of GSH and GPx enzymes was found to be statistically insignificant, whereas, the variance of MDA and SOD averages between the patient and control groups was found to be statistically significant (p<0.05). Hence, levels of MDA were elevated among the patients who endured Familial Mediterranean Fever disturbance. While, at the outset, the function of antioxidant enzymes such as SOD and GSH has shown a decline.
Conclusion: As a result of these grounds, alternative methods ought to be demonstrated in clinical applications for FMF patients, antioxidant enzymes might alter the underlying causes of the disease and its etiopathogenesis. Consequently, from our findings, we inferred that the reason for the progress and advancement of Familial Mediterranean Fever (FMF) disease might be the outcome of disruption and Inequity among the levels of antioxidants and oxidative stress (OS).

Anahtar Kelimeler

FMF GSH GPx SOD and MDA.

Etik Beyan

The study was approved by the Yüzüncü Yıl University Faculty of Medicine Clinical Research Ethics Committee. The present study strictly followed the principles outlined in the Declaration of Helsinki. Informed consent was obtained from the participants of this study.

Kaynakça

  • Akalin N, Bes C, Harmankaya O, Ertürk K, Okuturlar Y, Kumbasar B. (2015). Comparison of inflammation effects in the patients with familial mediterranean fever and dialysis patients. International Journal of Urology and Nephrology, 3(3), 82-89.
  • Alesh MB, Keti DB, Kisaarslan AP, Muhtaroğlu S, Taşkin, S. N. (2022). Hidden threat in familial Mediterranean fever: subclinical inflammation, oxidative stress and their relationship with vitamin D status. Turkish Journal of Medical Sciences, 52(1), 67-75.
  • Ansari MA, Scheff SW. (2010). Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex. Journal of Neuropathology & Experimental Neurology, 69(2), 155-167.
  • Arıtürk ÖK, Üreten K, Sarı M, Yazıhan N, Ermiş E, Ergüder İ. (2013). Relationship of paraoxonase-1, malondialdehyde and mean platelet volume with markers of atherosclerosis in familial Mediterranean fever: an observational study. Anadolu Kardiyol Derg, 13(4), 357-362.
  • Bedard K, Krause KH. (2007). The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiological reviews, 87(1), 245-313.
  • Beutler E, Duron O, Kelly B. (1963). Improved methods for determination of blood gluthatione. J Lab Clin Med, 61, 882-888.
  • Böhm EW, Buonfiglio F, Voigt A M, Bachmann P, Safi T, Pfeiffer N, Gericke A. (2023). Oxidative stress in the eye and its role in the pathophysiology of ocular diseases. Redox Biology, 102967.
  • Brik R, Shinawi M, Kepten I, Berant M, Gershoni-Baruch R. (1999). Familial Mediterranean fever: clinical and genetic characterization in a mixed pediatric population of Jewish and Arab patients. Pediatrics, 103(5), e70-e70.
  • Çekiç SD, Çetinkaya A, Avan AN, Apak R. (2013). Correlation of Total Antioxidant Capacity with Reactive Oxygen Species (ROS) Consumption Measured by Oxidative Conversion. J. Agric. Food Chem., 61(22), 5260-5270.
  • Demirkaya E, Ozen S, Saglam C, Turker T, Duzova A, Woo P, Konè-Paut I, Doglio M, Amarian G, Frenkel J. (2013). PReS-FINAL-2207: Results from a multicenter international registry of Familial Mediterranean Fever: validation of the new set of pediatric diagnostic criteria. Pediatric Rheumatology, 11(2), 1-2.
  • Didžiapetrienė J, Bublevič J, Smailytė G, Kazbarienė B, Stukas R. (2014). Significance of blood serum catalase activity and malondialdehyde level for survival prognosis of ovarian cancer patients. Medicina, 50(4), 204-208.
  • Dinç G, Fentoğlu Ö, Doğru A, İlhan İ, Kırzıoğlu FY, Orhan H. (2018). The evaluation of salivary oxidative stress in patients with familial Mediterranean fever and chronic periodontitis. Journal of periodontology, 89(9), 1112-1120.
  • Ediz L, Ozkol H, Tekeoglu I, Tuluce Y, Gulcu E, Koyuncu I. (2011). Increased oxidative stress in patients with familial Mediterranean fever during attack period. African health sciences, 11, 6-13.
  • Erden M, Ediz L, Hız Ö, Tuluce Y, Ozkol H, Toprak M, Demirdag F. (2012). Effect of colchicine on total antioxidant capacity, antioxidant enzymes and oxidative stress markers in patients with knee osteoarthritis. International Journal of Clinical Medicine, 3(05), 377-382.
  • Espinoza SE, Guo H, Fedarko N, DeZern A, Fried LP, Xue QL, Leng S, Beamer B, Walston JD. (2008). Glutathione peroxidase enzyme activity in aging. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 63(5), 505-509.
  • Forman HJ, Zhang H. (2021). Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nature Reviews Drug Discovery, 20(9), 689-709.
  • Gül A, Ozdogan H, Erer B, Ugurlu S, Kasapcopur O, Davis N, Sevgi S. (2015). Efficacy and safety of canakinumab inadolescents and adults with colchicine-resistant familial Mediterranean fever. Arthritis Research & Therapy, 17(243).
  • Gulcin İ. (2020). Antioxidants and antioxidant methods: An updated overview. Archives of toxicology, 94(3), 651-715
  • Gürbüz Ö, Bağci B, Hüzmeli C, Bağci G, Candan F. (2016). Glutathione-S-transferase variants are not associated with increased carotid intima-media thickness in turkish familial mediterranean fever patients. Archives of Rheumatology, 31(2), 112.
  • Gutteridge JM. (1995). Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clinical Chemistry, 41(12), 1819-1828.
  • Guzel S, Andican G, Seven A, Aslan M, Bolayirli M, Guzel EC, Hamuryudan V. (2012). Acute phase response and oxidative stress status in familial Mediterranean fever (FMF). Modern rheumatology, 22(3), 431-437.
  • Hybertson, B. M., Gao, B., Bose, S. K., & McCord, J. M. (2011). Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Molecular aspects of medicine, 32(4-6), 234-246.
  • Jin, S., & Kang, P. M. (2024). A systematic review on advances in management of oxidative stress-associated cardiovascular diseases. Antioxidants, 13(8), 923.
  • Karaguezyan K, Haroutjunian V, Mamiconyan R, Hakobian G, Nazaretian E, Hovsepyan L, Hoveyan G, Gevorkian E, Hovakimyan S, Zakarian A. (1996). Evidence of oxidative stress in erythrocyte phospholipid composition in the pathogenesis of familial Mediterranean fever (periodical disease). Journal of clinical pathology, 49(6), 453-455.
  • Kilic A, Varkal MA, Durmus MS, Yildiz I, Yıldırım ZNY, Turunc G, Oguz F, Sidal M, Omeroglu RE, Emre S. (2015). Relationship between clinical findings and genetic mutations in patients with familial Mediterranean fever. Pediatric Rheumatology, 13(1), 1-9.
  • Ktsoyan ZA, Beloborodova NV, Sedrakyan AM, Osipov GA, Khachatryan ZA, Manukyan GP, Arakelova KA, Hovhannisyan AI, Arakelyan AA, Ghazaryan KA. (2013). Management of familial Mediterranean fever by colchicine does not normalize the altered profile of microbial long chain fatty acids in the human metabolome. Frontiers in cellular and infection microbiology, 3, 2.
  • Kucuk A, Uslu AU, Arslan S, Balta S, Ozturk C, Uysal S, Kayrak M. (2016). Ischemia-modified albumin and atherosclerosis in patients with familial Mediterranean fever. Angiology, 67(5), 456-460.
  • Lancieri M, Bustaffa M, Palmeri S, Prigione I, Penco F, Papa R, Gattorno M. (2023). An update on familial Mediterranean fever. International Journal of Molecular Sciences, 24(11), 9584.
  • Lü JM, Lin PH, Yao Q, Chen C. (2010). Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. Journal of Cellular and Molecular Medicine, 14(4), 840-860.
  • Mattit H, Joma M, Al-Cheikh S, El-Khateeb M, Medlej-Hashim M, Salem N, Mégarbané A. (2006). Familial Mediterranean fever in the Syrian population: gene mutation frequencies, carrier rates and phenotype–genotype correlation. European journal of medical genetics, 49(6), 481-486.
  • Michiels C, Raes M, Toussaint O, Remacle J. (1994). Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-SOD for cell survival against oxidative stress. Free radical Biology and medicine, 17(3), 235-248.
  • Milenković J, Vojinović J, Debeljak M, Toplak N, Lazarević D, Avčin T, Jevtović-Stoimenov T, Pavlović D, Bojanić V, Milojković M. (2016). Distribution of MEFV gene mutations and R202Q polymorphism in the Serbian population and their influence on oxidative stress and clinical manifestations of inflammation. Pediatric Rheumatology, 14(1), 1-9.
  • Morano KA, Grant CM, Moye-Rowley WS. (2012). The response to heat shock and oxidative stress in Saccharomyces cerevisiae. Genetics, 190(4), 1157-1195.
  • Onur H, Aral H, Arica V, Bercem GA, Kasapcopur O. (2016). Vitamin D levels in children with familial Mediterranean fever. Pediatric Rheumatology, 14, 1-5.
  • Özer S, Yılmaz R, Sönmezgöz E, Karaaslan E, Taşkın S, Bütün İ, Demir O. (2015). Simple markers for subclinical inflammation in patients with Familial Mediterranean Fever. Medical Science Monitor: İnternational medical journal of experimental and clinical research, 21, 298.
  • Peters RS, Lehman TJ, Schwabe AD. (1983). Colchicine use for familial Mediterranean fever—observations associated with long-term treatment. Western Journal of Medicine, 138(1), 43.
  • Poljsak B, Šuput D, Milisav I. (2013). Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants. Oxidative Medicine and Cellular Longevity, 2013, 1-11.
  • Popov B, Gadjeva V, Valkanov P, Popova S, Tolekova A. (2003). Lipid peroxidation, superoxide dismutase and catalase activities in brain tumor tissues. Archives of physiology and biochemistry, 111(5), 455-459.
  • Rabinovich E. (2005). Severe disease in patients with rheumatoid arthritis carrying a mutation in the Mediterranean fever gene. Annals of the Rheumatic Diseases, 64(7), 1009-1014.
  • Rabinovich E, Livneh A, Langevitz P, Brezniak N, Shinar E, Pras M, Shinar Y. (2005). Severe disease in patients with rheumatoid arthritis carrying a mutation in the Mediterranean fever gene. Annals of the Rheumatic Diseases, 64(7), 1009-1014.
  • Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, Dhama K. (2014). Oxidative stress, prooxidants, and antioxidants: the interplay. BioMed research international, 2014.
  • Romano M, Garcia-Bournissen F, Piskin D, Rodoplu U, Piskin L, Elzagallaai AA, Honca T. (2022). Anti-inflammatory, antioxidant, and anti-atherosclerotic effects of natural supplements on patients with FMF-related AA amyloidosis: a non-randomized 24-week open-label interventional study. Life, 12(6), 896.
  • Salehzadeh F. (2015). Familial Mediterranean fever in Iran: a report from FMF registration center. International journal of rheumatology, 2015.
  • Santos DF, Simão S, Nóbrega C, Bragança J, Castelo‐Branco P, Araújo IM, Consortium AS. (2024). Oxidative stress and aging: synergies for age related diseases. FEBS letters, 598(17), 2074-2091.
  • Schwabe AD, Terasaki PI, Barnett EV, Territo MC, Klinenberg JR, Peters RS. (1977). Familial Mediterranean fever: recent advances in pathogenesis and management. Western Journal of Medicine, 127(1), 15.
  • Sharma SL, Chokshi SA, Chakraborti C. (2014). Enzymatic Antioxidants, Malondialdehyde, and Total Antioxidant Activity as Markers of Oxidative-Stress in Arthritis and Rheumatoid Arthritis. NHL Journal of Medical Sciences, 3(2).
  • Tufan A, LACHMANN H. (2020). Familial Mediterranean fever, from pathogenesis to treatment: a contemporary review. Turkish Journal of Medical Sciences, 50(10), 1591-1610.
  • Valko M, Morris H, Cronin M. (2005). Metals, toxicity and oxidative stress. Current medicinal chemistry, 12(10), 1161-1208.
  • Yilmaz R, Ozer S. (2010). A rare presentation of familial Mediterranean fever; acute scrotum and hydrocele amyloidosis. Iranian Journal of Pediatrics, 20(3), 367.
  • Zamora AJ, Andrade CD, Henares JAR. (2016). Antioxidant capacity, total phenols and color profile during the storage of selected plants used for infusion. Food Chemistry, 199(11), 339-346.
Toplam 50 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Kimya
Bölüm Orijinal Araştırma Makaleleri
Yazarlar

Amani Yasin 0000-0001-7695-7755

Halit Demir 0000-0001-5598-2601

Lokman Üstyol 0009-0007-4638-9268

Şükran Akgeyik 0009-0001-4485-103X

Rabia Akgeyik 0009-0004-6661-5769

Canan Demir 0000-0002-4204-9756

Erken Görünüm Tarihi 29 Nisan 2025
Yayımlanma Tarihi 30 Nisan 2025
Gönderilme Tarihi 23 Ağustos 2024
Kabul Tarihi 20 Mart 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 18 Sayı: 1

Kaynak Göster

APA Yasin, A., Demir, H., Üstyol, L., Akgeyik, Ş., vd. (2025). Antioxidant Contents and Oxidative Stress Markers in Pediatric Familial Mediterranean Fever. Van Sağlık Bilimleri Dergisi, 18(1), 17-39. https://doi.org/10.52976/vansaglik.1535898
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