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Hemispheric Differences in Brain Diffusion Values in 3 Tesla MR

Yıl 2019, Cilt: 72 Sayı: 2, 144 - 149, 02.10.2019

Elif Peker

Öz

Objectives: The purpose of this study is to demonstrate the variability of the diffusion values in different anatomical regions of the brain.

Materials and Methods: 3T diffusion MR images of 190 patients underwent brain imaging were evaluated. Patients were divided into groups according to ages: 20-29, 30-39, 40-49, 50-59, 60-69. The ROIs were placed in the frontal, temporal, occipital, parietal lobes, cerebellum, thalamus, to be of equal size in both hemispheres. The ADC values obtained were standardized by dividing by the ADC values obtained from the ventricle.

Results: One hundred and ninety patients, 97 men and 93 women, aged between 20 and 69 years, were included in the study.The mean ADC values were: frontal lobe=726,8x10-3 mm2/sec (532-945x10-3 mm2/sec), cerebellum=680x10-3 mm2/sec (586-816x10-3 mm2
/(609-996x10-3 mm2/sec) in the temporal lobe=791,2x10-3 mm2/sec (448-945x10-3 mm2/sec), parietal=789,9x10-3 mm2/sec (671-935 x10-3 mm2/sec) and in the occipital=790,6x10-3 mm2/sec (690-973x10-3 mm2/sec). Significant differences were found in the frontal, temporal lobes and cerebellum (p=0.600, p=0.430, p=0.227, respectively) in the thalamus, parietal and occipital lobes when the whole brain was evaluated. 0.011, p=0.000, p=0.000). There was a significant difference between all age groups for all lobes. When the frontal lobe, cerebellum, thalamus, temporal, parietal and occipital lobes were evaluated, the highest ADC values were obtained between ages 60-69 (748±44×10-3 mm2/sec, 689±34×10-3 mm2/sec, 731±41x10-3 mm2/sec, 827+41x10-3 mm2/sec, 809+56x10-3 mm2/sec, 821+56x10-3 mm2/sec).

Conclusion: In different anatomical regions of brain, diffusion values are different.

Anahtar Kelimeler

Diffusion Magnetic Resonance Apparent Diffusion Coefficient Hemispheric Differences

Etik Beyan

Etik Kurul Onayı: Çalışma için Ankara Üniversitesi Tıp Fakültesi Klinik Araştırmalar Etik Kurul’undan etik kurul onayı alınmıştır (Karar no: 03-201-19).

Destekleyen Kurum

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Proje Numarası

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Teşekkür

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Kaynakça

  • 1. Helenius J, Soinne L, Perkiӓ J, Salonen O, Kangasmӓki A, Kaste M, Carano RAD, Aronen HJ, Tatlisumak T. Diffusion-Weighted MR Imaging in Normal Human Brains in Various Age Groups. AJNR. 2002;23:194-200.
  • 2. Shimony JS, McKinstry RC, Erbil A, et al. Quantitative diffusion-tensor anisotropy brain MR imaging: normative human data and anatomic analysis. Radiol. 1999;212:770-784.
  • 3. Naganawa S, Sato K, Katagiri T, et al. Regional ADC values of the normal brain: differences due to age, gender, and laterality. Eur Radiol. 2003;13:6-13.
  • 4. Fabiano AJ, Horsfield MA, Bakshi R. Interhemispheric Asymmetry of Brain Diffusivity in Normal Individuals: A Diffusion-Weighted MR Imaging Study. AJNR. Am J Neuroradiol. 2005;26:1089-1094.
  • 5. Harada K, Fujita N, Sakurai K, et al. Diffusion imaging of the human brain: a new pulse sequence application for a 1.5-T standard MR system. AJNR Am J Neuroradiol. 1991;12:1143–1148.
  • 6. Good CD, Johnsrude I, Ashburner J, et al. Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel based morphometric analysis of 465 normal adult human brains. Neuroimage. 2001;14:685-700.
  • 7. Penhune VB, Zatorre RJ, MacDonald JD, et al. Interhemispheric anatomical differences in human primary auditory cortex: probabilistic mapping and volume measurement from magnetic resonance scans. Cereb Cortex. 1996;6:661-672.
  • 8. Szabo CA, Lancaster JL, Xiong J, et al. MR imaging volumetry of subcortical structures and cerebellar hemispheres in normal persons. AJNR Am J Neuroradiol. 2003;24:644-647.
  • 9. Willis MW, Ketter TA, Kimbrell TA, et al. Age, sex, and laterality effects on cerebral glucose metabolism in healthy adults. Psychiatry Res. 2002;114:23-37.
  • 10. Gideon P, Thomsen C, Henriksen O. Increased self-diffusion of brain water in normal aging. J Magn Reson Imaging. 1994;4:185-188.
  • 11. Nusbaum AO, Tang CY, Buchsbaum MS, et al. Regional and global changes in cerebral diffusion with normal aging. Am J Neuroradiol. 2001;22:136-142.
  • 12. Hosoda T, Nakajima H, Honjo H. Estrogen protects neuronal cells from amyloid beta-induced apoptotic cell death. Neuroreport. 2001;12:1965-1970.
  • 13. Savaskan E, Olivieri G, Meier F, et al. Hippocampal estrogen betareceptor immunoreactivity is increased in Alzheimer’s disease. Brain Res. 2001;908:113-119

Yıl 2019, Cilt: 72 Sayı: 2, 144 - 149, 02.10.2019

Elif Peker

Öz

Proje Numarası

-

Kaynakça

  • 1. Helenius J, Soinne L, Perkiӓ J, Salonen O, Kangasmӓki A, Kaste M, Carano RAD, Aronen HJ, Tatlisumak T. Diffusion-Weighted MR Imaging in Normal Human Brains in Various Age Groups. AJNR. 2002;23:194-200.
  • 2. Shimony JS, McKinstry RC, Erbil A, et al. Quantitative diffusion-tensor anisotropy brain MR imaging: normative human data and anatomic analysis. Radiol. 1999;212:770-784.
  • 3. Naganawa S, Sato K, Katagiri T, et al. Regional ADC values of the normal brain: differences due to age, gender, and laterality. Eur Radiol. 2003;13:6-13.
  • 4. Fabiano AJ, Horsfield MA, Bakshi R. Interhemispheric Asymmetry of Brain Diffusivity in Normal Individuals: A Diffusion-Weighted MR Imaging Study. AJNR. Am J Neuroradiol. 2005;26:1089-1094.
  • 5. Harada K, Fujita N, Sakurai K, et al. Diffusion imaging of the human brain: a new pulse sequence application for a 1.5-T standard MR system. AJNR Am J Neuroradiol. 1991;12:1143–1148.
  • 6. Good CD, Johnsrude I, Ashburner J, et al. Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel based morphometric analysis of 465 normal adult human brains. Neuroimage. 2001;14:685-700.
  • 7. Penhune VB, Zatorre RJ, MacDonald JD, et al. Interhemispheric anatomical differences in human primary auditory cortex: probabilistic mapping and volume measurement from magnetic resonance scans. Cereb Cortex. 1996;6:661-672.
  • 8. Szabo CA, Lancaster JL, Xiong J, et al. MR imaging volumetry of subcortical structures and cerebellar hemispheres in normal persons. AJNR Am J Neuroradiol. 2003;24:644-647.
  • 9. Willis MW, Ketter TA, Kimbrell TA, et al. Age, sex, and laterality effects on cerebral glucose metabolism in healthy adults. Psychiatry Res. 2002;114:23-37.
  • 10. Gideon P, Thomsen C, Henriksen O. Increased self-diffusion of brain water in normal aging. J Magn Reson Imaging. 1994;4:185-188.
  • 11. Nusbaum AO, Tang CY, Buchsbaum MS, et al. Regional and global changes in cerebral diffusion with normal aging. Am J Neuroradiol. 2001;22:136-142.
  • 12. Hosoda T, Nakajima H, Honjo H. Estrogen protects neuronal cells from amyloid beta-induced apoptotic cell death. Neuroreport. 2001;12:1965-1970.
  • 13. Savaskan E, Olivieri G, Meier F, et al. Hippocampal estrogen betareceptor immunoreactivity is increased in Alzheimer’s disease. Brain Res. 2001;908:113-119
Toplam 13 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Radyoloji ve Organ Görüntüleme
Bölüm Makaleler
Yazarlar

Elif Peker 0000-0002-1973-7905

Proje Numarası -
Yayımlanma Tarihi 2 Ekim 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 72 Sayı: 2

Kaynak Göster

APA Peker, E. (2019). Hemispheric Differences in Brain Diffusion Values in 3 Tesla MR. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 72(2), 144-149. https://doi.org/10.4274/atfm.galenos.2019.74946
AMA Peker E. Hemispheric Differences in Brain Diffusion Values in 3 Tesla MR. Ankara Üniversitesi Tıp Fakültesi Mecmuası. Ekim 2019;72(2):144-149. doi:10.4274/atfm.galenos.2019.74946
Chicago Peker, Elif. “Hemispheric Differences in Brain Diffusion Values in 3 Tesla MR”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 72, sy. 2 (Ekim 2019): 144-49. https://doi.org/10.4274/atfm.galenos.2019.74946.
EndNote Peker E (01 Ekim 2019) Hemispheric Differences in Brain Diffusion Values in 3 Tesla MR. Ankara Üniversitesi Tıp Fakültesi Mecmuası 72 2 144–149.
IEEE E. Peker, “Hemispheric Differences in Brain Diffusion Values in 3 Tesla MR”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 72, sy. 2, ss. 144–149, 2019, doi: 10.4274/atfm.galenos.2019.74946.
ISNAD Peker, Elif. “Hemispheric Differences in Brain Diffusion Values in 3 Tesla MR”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 72/2 (Ekim 2019), 144-149. https://doi.org/10.4274/atfm.galenos.2019.74946.
JAMA Peker E. Hemispheric Differences in Brain Diffusion Values in 3 Tesla MR. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2019;72:144–149.
MLA Peker, Elif. “Hemispheric Differences in Brain Diffusion Values in 3 Tesla MR”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 72, sy. 2, 2019, ss. 144-9, doi:10.4274/atfm.galenos.2019.74946.
Vancouver Peker E. Hemispheric Differences in Brain Diffusion Values in 3 Tesla MR. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2019;72(2):144-9.
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